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BMS-599626 hydrochloride
CAS No. 873837-23-1
BMS-599626 hydrochloride ( AC480;BMS-599626 HCl;BMS599626;BMS 599626;AC-480 )
Catalog No. M16355 CAS No. 873837-23-1
BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 78 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 228 | In Stock |
|
| 50MG | 402 | In Stock |
|
| 100MG | 593 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-599626 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
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DescriptionBMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM; displays 8-fold less potency to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc; inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2; shows potent antitumor activity in a human breast tumor KPL-4 xenograft; orally efficacious.Breast Cancer Phase 1 Discontinued
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SynonymsAC480;BMS-599626 HCl;BMS599626;BMS 599626;AC-480
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number873837-23-1
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Formula Weight567.01
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Molecular FormulaC27H28ClFN8O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=C2C(=NC=NN2C=C1NC(=O)OCC3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl
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Chemical NameCarbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gavai AV, et al. J Med Chem. 2009 Nov 12;52(21):6527-30.
2. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
3. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
2. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
3. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
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