BMS-599626 hydrochloride

Research use only, not for human use.

BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.

BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM; displays 8-fold less potency to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc; inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2; shows potent antitumor activity in a human breast tumor KPL-4 xenograft; orally efficacious.Breast Cancer Phase 1 Discontinued

AC480;BMS-599626 HCl;BMS599626;BMS 599626;AC-480

Angiogenesis

EGFR

EGFR

Cancer

Breast Cancer

873837-23-1

567.01

C27H28ClFN8O3

>98% (HPLC)

10 mM in DMSO

CC1=C2C(=NC=NN2C=C1NC(=O)OCC3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl

Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride (9CI)

(-20℃)

With Ice Pack

≥ 2 years